So, what the heck is going on over at Cadence? They've hired the Smalltalk/StrongTalk/Java-HotSpot wizard from Sun (Gilad Bracha) and a couple of key Smalltalk folks from Cincom. One of whom (Eliot Miranda, at least) is like Bracha, a very knowledgeable person at the compiler/hotspot optimization level.
Visual Works has a pretty mature compiler/runtime, but that has to be a loss.
Sun is just getting started with dynamic languages on the JVM... that seems like more of a loss.
Interesting. Cadence has been one of the leaders in computer-aided electronics design for 15+ years. Way back when they were one of the first to incorporate a dialect of Scheme into their design tools. That led to or was closely associated with EDIF, the Electronic Design Interchange Format, based on Scheme/Lisp syntax. (Way better than today's XML, but... another day.)